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SINGULAIR, a once-a-day medication for the treatment of asthma and seasonal allergies. Learn more about
SINGULAIR asthma and seasonal
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www.singulair.comApr 3, 2008
... Singulair (montelukast) is used to prevent asthma attacks in adults and children as young as 12 months old. Includes
Singulair side effects,
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Singulair (Montelukast Sodium), drug uses, dosage, side effects, drug interactions, warnings, and patient labeling.
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Singulair Oral including side effects, drug interactions, images and pictures, medication uses, warnings, user ratings and
...www.webmd.comMontelukast (trade name
Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of
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... Singulair is a medicine in the drug class known as leukotriene
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Wikipedia
Montelukast
From Wikipedia, the free encyclopedia
(Redirected from Singulair)
Montelukast
Systematic (IUPAC) name
2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]
phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]
sulfanylmethyl]cyclopropyl]acetic acid
Identifiers
CAS number
158966-92-8
ATC code
R03DC03
PubChem
60951
DrugBank
APRD00434
Chemical data
Formula
C35H36ClNO3S
Mol. mass
586.184 g/mol
SMILES
eMolecules & PubChem
Pharmacokinetic data
Bioavailability
63% to 73%
Protein binding
99%
Metabolism
Hepatic (CYP3A4 and CYP2C9-mediated)
Half life
2.7-5.5 hours
Excretion
Biliary
Therapeutic considerations
Pregnancy cat.
B (U.S.), B1 (Au)
Legal status
℞-only (U.S.), POM (UK), S4 (Au)
Routes
Oral
Montelukast (trade name Singulair) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.[1] It is usually administered orally. Montelukast is a CysLT1 antagonist; that is it blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.
Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other allergy medications such as theophylline. Another leukotriene receptor antagonist is zafirlukast (Accolate), taken once daily. zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.
The Mont in Montelukast stands for Montreal, the place where Merck developed the drug.[citation needed]
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